Ethan’s thesis research in the Speshock Lab investigates how cobalt and cobalt‑oxide nanoparticles influence human lung fibroblast cells and contribute to the development of idiopathic pulmonary fibrosis. This work is supported by the first NIH grant ever awarded to a faculty member at Tarleton State University, offering a significant opportunity to advance both the understanding of nanoparticle toxicity and the university’s growing research profile. By employing multiple in vitro cell models—including single‑cell, extracellular matrix, and coculture systems—the study rigorously compares their effectiveness in replicating fibrotic responses. Using advanced techniques such as qRT‑PCR, Western blotting, and immunofluorescence, key biomarkers, including IL‑6, MMP‑7, α‑SMA, collagen, toll‑like receptors, and surfactant proteins, are measured to track fibroblast differentiation. His work aims to deepen the scientific understanding of nanoparticle‑induced lung disease while establishing robust models for future mechanistic studies, providing essential tools to assess fibrosis development and guide responsible innovation of nanomaterials in both medicine and industry.

During the fall semester of 2025, Ethan contributed to the nationally recognized SEA‑GENES program through the Howard Hughes Medical Institute (HHMI), successfully isolating gene 091 of the phage Thetabob. Under the mentorship of Dr. Harold Rathburn, he carried out advanced molecular biology techniques, including DNA extraction, isothermal assembly, gel extraction, and plasmid cloning—skills essential to modern genetic research. These hands‑on assays deepened his expertise in gene isolation and characterization while advancing the SEA‑GENES program’s mission to uncover novel genetic functions. His work supported the broader scientific effort to expand our understanding of phage genomics and explore their potential as alternatives to traditional antibiotics.

In October 2021, Ethan observed a robotic ileocecectomy performed by Dr. Scott Carpenter for a rare volvulus classified as a cecal bascule. Following the procedure, he conducted a comprehensive literature review for the resulting case study, which is currently awaiting submission for peer review.